Skip to content Skip to sidebar

Site logo

  • Home
  • Videos
  • Clinical studies
  • White papers
  • Wellness facts
  • History
  • Contact
  • About us
Date: September 26, 2016December 13, 2016 Author: admin Comments: 0
  • Category Clinical studies
  • Category Heat Shock Proteins

Effect of heat acclimation on heat shock protein 72 and interleukin-10 in humans. (,23)

In order to verify the effects of heat and exercise acclimation (HA) on resting and exercise-induced expression of plasma and leukocyte heat shock protein 72 (Hsp72) in humans, nine healthy young male volunteers (25.0 ± 0.7 years, 80.5 ± 2.0 kg, 180 ± 2 cm, mean ± SE) exercised for 60 min in a hot, dry environment (40 ± 0°C and 45 ± 0% relative humidity) for 11 days. The protocol consisted of running on a treadmill using a controlled hyperthermia technique in which the work rate was adjusted to elevate the rectal temperature by 1°C in 30 min and maintain it elevated for another 30 min. Before and after the HA, the volunteers performed a heat stress test (HST) at 50% of their individual maximal power output for 90 min in the same environment. Blood was drawn before (REST), immediately after (POST) and 1 h after (1 h POST) HST, and plasma and leukocytes were separated and stored. Subjects showed expected adaptations to HA: reduced exercise rectal and mean skin temperatures and heart rate, and augmented sweat rate and exercise tolerance. In HST1, plasma Hsp72 increased from REST to POST and then returned to resting values 1 h POST (REST: 1.11 ± 0.07, POST: 1.48 ± 0.10, 1 h POST: 1.22 ± 0.11 ng mL?1, p < 0.05). In HST2, there was no change in plasma Hsp72 (REST: 0.94 ± 0.08, POST: 1.20 ± 0.15, 1 h POST: 1.17 ± 0.16 ng mL?1, p > 0.05). HA increased resting levels of intracellular Hsp72 (HST1: 1 ± 0.02 and HST2: 4.2 ± 1.2 density units, p < 0.05). Exercise-induced increased intracellular Hsp72 expression was observed on HST1 (HST1: REST, 1 ± 0.02 vs. POST, 2.9 ± 0.9 density units, mean ± SE, p < 0.05) but was inhibited on HST2 (HST2: REST, 4.2 ± 1.2 vs. POST, 4.4 ± 1.1 density units, p > 0.05). Regression analysis showed that the lower the pre-exercise expression of intracellular Hsp72, the higher the exercise-induced increase (R = ?0.85, p < 0.05). In conclusion, HA increased resting leukocyte Hsp72 levels and inhibited exercise-induced expression. This intracellular adaptation probably induces thermotolerance. In addition, the non-increase in plasma Hsp72 after HA may be related to lower stress at the cellular level in the acclimated individuals.

  • #Exercise in heat
  • #Heat acclimation
  • #HSPs

Post navigation

Previous Post Continuous low-level heat wrap therapy for treating acute nonspecific low back pain.
Next Post Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

The section contains widgets

Account member

  • Login
    • Sign up
    • Change Password

Benefit topic

Choose a keyword

Acclimation|Addiction|Aging Alcoholism|Alzheimers disease| Appetite
------------------------------------
BDNF|Biomechanical adaptations|Blood-cells|Blood pressure|Body-composition|Brain|Brain lymphatic
------------------------------------
Calories | Cancer | Cardiovascular adjustments | Catecholamines Chronic fatigue syndrome | Chronic Traumatic Encephalopathy (CTE) | Cognition | Core temperature
------------------------------------
Depression | Diabetes | Diet | Drug-use
------------------------------------
Endocrine-system | Endorphins Energy expenditure | Exercise Exercise in heat
------------------------------------
Fatigue | Fibromyalgia | Fitness | Flexibility | Fox O3 gene
------------------------------------
Glucose tolerance | Glycogen
------------------------------------
Head cooling | Health benefits Heart disease | Heat | Heat acclimation | Heat stress | Heat treatment | Hgh | Hormonal response | Hsps | Hyperthermia
------------------------------------
Insulin
------------------------------------
Lactate-threshold | Learning | Longevity | Lymphatic-system
------------------------------------
Meditation|Memory | Metabolism|Muscle adaptation|Muscle-metabolism & circulation|Muscle re-growth/Reduce atrophy
------------------------------------
Neurogenesis|Norepinephrine
------------------------------------
Obesity
------------------------------------
Pain | Prolactin
------------------------------------
Range-of-motion | Relaxation Research
------------------------------------
Sauna | Sleep | Strength-training | Stress | Sweating
------------------------------------
Telomeres | Thermal therapy | Thermogenesis | Thermoregulatory adaptations Thermotolerance
------------------------------------
Weight-loss

The section contains information on copyright and first-level footer navigation

Copyright © 2023

  • Home
  • Videos
  • Clinical studies
  • White papers
  • Wellness facts
  • History
  • Contact
  • About us